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In xenografts, luteolin (100 mg/kg IV) reduced tumor burden and prolonged survival without systemic toxicity, supporting its potential as a safe adjunct targeting tumor stemness ( In Ca Ski cervical cancer cells, luteolin (25100 M) inhibited proliferation and induced intrinsic apoptosis characterized by caspase activation and mitochondrial dysfunction ( Transcriptomic analyses indicate that luteolin targets genes involved in IL-17 signaling, oxidative stress regulation, and homologous recombination repair (Zhao et al., 2023)

Nature 446 , 801805 (2007)

doi: 10.1016/j.jbc.2021.101388

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